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Article

Inactivation of p16INK4a in primary tumors and cell lines of head and neck squamous cell carcinoma.

Molecules and cells - 31 Oct 2000

Kim H S, Chung W B, Hong S H, Kim J A, Na S Y, Jang H J, Sohn Y K, Kim J W

Abstract excerpt

Inactivation of the p16INK4a gene by mutation and deletion is common in head and neck squamous cell carcinoma (HNSCC). The present study demonstrates that hypermethylation of the 5' CpG islands can serve as an alternative mechanism for the inactivation of the p16INK4a gene in this tumor. We studied 11 HNSCC cell lines and 17 oral squamous cell carcinoma (OSCC) primary tumors for p16INK4a gene status by...

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Share to Carcinoma, Squamous Cell
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

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Share to Mouth Neoplasms

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Identifiers

PMID: 11101148
DOI: 10.1007/s10059-000-0557-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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