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Article

A collaborative screening program for the discovery of inhibitors of HCV NS2/3 cis-cleaving protease activity.

Journal of biomolecular screening - 1 Apr 2002

Whitney Mike, Stack Jeffrey H, Darke Paul L, Zheng Wei, Terzo Joe, Inglese Jim, Strulovici Berta, Kuo Lawrence C, Pollock Brian A

Abstract excerpt

This report describes the development of a cell-based assay for high-throughput screening and detection of small-molecule inhibitors for hepatitis C virus (HCV) NS2/3 protease. The HCV NS2/3 protease is essential for the normal infectious cycle of HCV. Generation of a cell-based assay for this cis-acting viral protease involved reporter constructs in which the NS2/3 protease sequence was inserted between the...

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PMID: 12026885
DOI: 10.1177/108705710200700208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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