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Article

(C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer.

Proceedings of the National Academy of Sciences of the United States of America - 6 Dec 1994

Zenklusen J C, Bièche I, Lidereau R, Conti C J

Abstract excerpt

Loss of heterozygosity in human chromosome 7q was studied to determine the location of a putative tumor suppressor gene. Twenty-six of 31 cases studied presented loss of heterozygosity at one or more loci on chromosome 7q. Eighty-three percent loss of heterozygosity (in 11 informative cases) was detected by using the (C-A)n microsatellite repeat marker D7S522 at 7q31.1-7q31.2. These results suggest that a tumor...

Topics

Alleles
Breast Neoplasms
Chromosome Aberrations
Chromosome Mapping
Chromosomes, Human, Pair 7
DNA
DNA, Neoplasm
DNA, Satellite
Humans
Leukocytes
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

Restriction Mapping

Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 7991599
DOI: 10.1073/pnas.91.25.12155
PMCID: PMC45395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7991599-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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