Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene.

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Article

Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene.

Oncogene - 20 Jul 1995

Zenklusen J C, Weitzel J N, Ball H G, Conti C J

Abstract excerpt

We studied loss of heterozygosity (LOH) in chromosome 7q in order to determine the location of a putative tumor suppressor gene (TSG) in human epithelial ovarian carcinomas. Samples were obtained from 26 primary ovarian carcinomas at the time of staging laparotomy. Paired normal and tumoral DNAs...

Topics

Adult
Aged
Alleles
Carcinoma
Chromosomes, Human, Pair 7
DNA
DNA, Satellite
Female
Gene Deletion
Genes, Tumor Suppressor
Genetic Markers
Heterozygote
Humans
Middle Aged
Ovarian Neoplasms
Polymerase Chain Reaction
Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 7624150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7624150-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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