Article
An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma.
Oncogene - 23 Jan 2003
Wang Suna, Mori Yuriko, Sato Fumiaki, Yin Jing, Xu Yan, Zou Tong-Tong, Olaru Andreea, Kimos Martha C, Perry Kellie, Selaru Florin M, Deacu Elena, Sun Menghong, Shi Ying-Chang, Shibata David, Abraham John M, Greenwald Bruce D, Meltzer Stephen J
Abstract excerpt
Frequent loss of heterozygosity (LOH) on human chromosome 7q31 has been reported in numerous malignancies. Suppressor of tumorigenicity 7 (ST7) has been identified as a candidate tumor suppressor gene in this region. To identify whether 7q31 and genetic alterations of ST7 were involved in human esophageal carcinogenesis, we performed LOH mapping of a 5.4 cM region at 7q31-q35 in 43 primary esophageal carcinomas,...
Topics
- Adenocarcinoma
- Carcinoma
- Chromosomes, Human, Pair 7
- DNA, Intergenic
- Esophageal Neoplasms
- Gene Expression Regulation, Neoplastic
- Humans
- Introns
- Loss of Heterozygosity
- Mutation