Article
Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis.
Blood - 21 Jun 2012
Jerez Andres, Sugimoto Yuka, Makishima Hideki, Verma Amit, Jankowska Anna M, Przychodzen Bartlomiej, Visconte Valeria, Tiu Ramon V, O'Keefe Christine L, Mohamedali Azim M, Kulasekararaj Austin G, Pellagatti Andrea, McGraw Kathy, Muramatsu Hideki, Moliterno Alison R, Sekeres Mikkael A, McDevitt Michael A, Kojima Seiji, List Alan, Boultwood Jacqueline, Mufti Ghulam J, Maciejewski Jaroslaw P
Abstract excerpt
Loss of heterozygosity affecting chromosome 7q is common in acute myeloid leukemia and myelodysplastic syndromes, pointing toward the essential role of this region in disease phenotype and clonal evolution. The higher resolution offered by recently developed genomic platforms may be used to establish more precise clinical correlations and identify specific target genes. We analyzed a series of patients with...
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