Article
Frequent loss of heterozygosity of the long arm of chromosome 7 is closely associated with progression of human gastric carcinomas.
International journal of cancer - 1 Dec 1994
Kuniyasu H, Yasui W, Yokozaki H, Akagi M, Akama Y, Kitahara K, Fujii K, Tahara E
Abstract excerpt
Loss of heterozygosity (LOH) on the long arm of chromosome 7 was examined using 5 polymorphic marker probes on 98 gastric carcinomas to elucidate a novel locus for development and progression of the tumors. Twenty-six (32%) of 82 informative cases showed LOH on 7q on at least one locus of 5 loci....
Topics
- Adenocarcinoma
- Alleles
- Chromosome Mapping
- Chromosomes, Human, Pair 7
- DNA Probes
- Gene Deletion
- Genetic Markers
- Heterozygote
- Humans
- Neoplasm Metastasis
- Neoplasm Staging
- Stomach Neoplasms