Article
Microsatellite analyses of loci at 7q31.3-q36 reveal a minimum of two common regions of deletion in nasopharyngeal carcinoma.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 1 Mar 2002
Tan Guolin, Xiao Jianyun, Tian Yongqian, Dong Longnwen, Jiang Nin, Zhan Fenfang, Li Guiyuan
Abstract excerpt
OBJECTIVE: Our goal was to better define the extent and specificity of deletion in the 7q32-qter chromosomal region in nasopharyngeal carcinoma (NPC). DESIGN AND SETTING: Polymerase chain reaction-based deletion analysis was performed on DNA samples from 24 paired NPCs and corresponding germlines using 13 microsatellite markers mapped to chromosome subbands 7q31.3-q36. RESULTS: Loss of heterozygosity of at least...
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