Article
Expression of cyclic adenosine 3',5'-monophosphate (cAMP)-responsive element binding protein and inducible-cAMP early repressor genes in growth hormone-secreting pituitary adenomas with or without mutations of the Gsalpha gene.
The Journal of clinical endocrinology and metabolism - 1 May 2001
Peri A, Conforti B, Baglioni-Peri S, Luciani P, Cioppi F, Buci L, Corbetta S, Ballaré E, Serio M, Spada A
Abstract excerpt
In about 30-40% of GH-secreting adenomas, gain-of-function mutations of the Gsalpha gene, which convert this gene into an oncogene termed gsp, occur. Gsalpha mutations have been related to pituitary tumorigenesis. We focused on 2 nuclear transcription factors that are final targets of the cAMP-dependent pathway and are positively regulated by cAMP signaling, i.e. the cAMP-responsive element binding protein (CREB)...
Topics
- Adenoma
- Adolescent
- Adult
- Aged
- Base Sequence
- Cyclic AMP Response Element Modulator
- Cyclic AMP Response Element-Binding Protein
- DNA-Binding Proteins
- Female