Article
Transforming and c-fos promoter/enhancer-stimulating activities of a stimulatory GDP/GTP exchange protein for small GTP-binding proteins.
The Journal of biological chemistry - 15 Jan 1992
Fujioka H, Kaibuchi K, Kishi K, Yamamoto T, Kawamura M, Sakoda T, Mizuno T, Takai Y
Abstract excerpt
smg GDP dissociation stimulator (GDS) is a stimulatory GDP/GTP exchange protein for a group of ras p21-like small GTP-binding proteins (G proteins) including c-Ki-ras p21, smg p21A, smg p21B, and rhoA p21. smg GDS converts the GDP-bound inactive form to the GTP-bound active form of each small G protein by stimulating their GDP/GTP exchange reaction in a cell-free system. The point-mutated c-Ki-ras p21...
Topics
- 3T3 Cells
- Animals
- Blotting, Western
- Cell Line, Transformed
- Enhancer Elements, Genetic
- Enzyme Activation
- Eukaryotic Initiation Factor-2
- GTP-Binding Proteins
- Gene Expression
- Guanine Nucleotide Exchange Factors