Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The common molecular genetic alterations in Dukes' B and C colorectal carcinomas are not short-term prognostic indicators of survival.

International journal of cancer - 15 Dec 1994

Dix B R, Robbins P, Soong R, Jenner D, House A K, Iacopetta B J

Abstract excerpt

Our study was undertaken to determine the prognostic significance of several common genetic alterations observed in colorectal carcinomas. We have previously analysed loss of heterozygosity of the MCC, APC, p53 and DCC tumour suppressor gene loci as well as p53 gene mutations and protein over-expression in a series of 100 Dukes' stage B and C colorectal tumours obtained at surgery. To extend our observations of...

Topics

Adenocarcinoma
Aged
Colorectal Neoplasms
Female
Genes, APC
Genes, ras
Humans
Male
Mutation
Neoplasm Staging
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prognosis

Prospective Studies

Survival Analysis

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 7989112
DOI: 10.1002/ijc.2910590606

Genes

APC
DCC
MCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7989112-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The common molecular genetic alterations in Dukes' B and C colorectal carcinomas are not short-term prognostic indicators of survival.PMID 7989112Read ↗

p53 alterations are associated with improved prognosis in distal colonic carcinomas.Semantic proximity Read ↗

Clinical significance of p53, K-ras and DCC gene alterations in the stage I-II colorectal cancers.Semantic proximity Read ↗

P53 alterations have no prognostic or predictive significance in Dukes' C rectal carcinomas.Semantic proximity Read ↗

Low frequency and late occurrence of p53 and dcc aberrations in colorectal tumours.Semantic proximity Read ↗

<i>p53</i> and K-<i>ras</i> Gene Mutations Correlate With Tumor Aggressiveness But Are Not of Routine Prognostic Value in Colorectal CancerSemantic proximity Read ↗

The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma.Semantic proximity Read ↗

The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma.Semantic proximity Read ↗

Staining patterns of p53 immunohistochemistry and their biological significance in colorectal cancer.Semantic proximity Read ↗

p53 and Ki-ras as prognostic factors for Dukes' stage B colorectal cancer.Semantic proximity Read ↗

Expression of p53 protein in invasive colorectal carcinomas of different histologic types.Semantic proximity Read ↗

Molecular detection of APC, K- ras, and p53 mutations in the serum of colorectal cancer patients as circulating biomarkers.Semantic proximity Read ↗

Characterisation of p53 status at the gene, chromosomal and protein levels in oesophageal adenocarcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.