Article
RCC1, a regulator of mitosis, is essential for DNA replication.
Molecular and cellular biology - 1 Aug 1992
Dasso M, Nishitani H, Kornbluth S, Nishimoto T, Newport J W
Abstract excerpt
Temperature-sensitive mutants in the RCC1 gene of BHK cells fail to maintain a correct temporal order of the cell cycle and will prematurely condense their chromosomes and enter mitosis at the restrictive temperature without having completed S phase. We have used Xenopus egg extracts to investigate the role that RCC1 plays in interphase nuclear functions and how this role might contribute to the known phenotype...
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