Article
RCC1, a regulator of mitosis, is essential for DNA replication.
Molecular and cellular biology - 1 Aug 1992
Dasso M, Nishitani H, Kornbluth S, Nishimoto T, Newport J W
Abstract excerpt
Temperature-sensitive mutants in the RCC1 gene of BHK cells fail to maintain a correct temporal order of the cell cycle and will prematurely condense their chromosomes and enter mitosis at the restrictive temperature without having completed S phase. We have used Xenopus egg extracts to investiga...
Topics
- Animals
- Cell Cycle Proteins
- Cell Line
- Chromatin
- Cricetinae
- DNA Replication
- DNA-Binding Proteins
- Escherichia coli
- Genes, Regulator
- Guanine Nucleotide Exchange Factors
- Kinetics
- Mitosis
- Mutation
- Nuclear Proteins
- Nucleosomes
- Oocytes
- Plasmids
- Recombinant Proteins