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Article

Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression.

The Journal of cell biology - 1 May 1994

Kornbluth S, Dasso M, Newport J

Abstract excerpt

TC4, a ras-like G protein, has been implicated in the feedback pathway linking the onset of mitosis to the completion of DNA replication. In this report we find distinct roles for TC4 in both nuclear assembly and cell cycle progression. Mutant and wild-type forms of TC4 were added to Xenopus egg...

Topics

Amino Acid Sequence
Animals
Base Sequence
Biological Transport
CDC2 Protein Kinase
Cell Cycle
Cell Nucleus
DNA
DNA Replication
Guanosine Triphosphate
Humans
Mitosis
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nuclear Proteins

Signal Transduction

Xenopus

ran GTP-Binding Protein

Source

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Identifiers

PMID: 8188741
DOI: 10.1083/jcb.125.4.705
PMCID: PMC2120068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8188741-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression.PMID 8188741Read ↗

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