Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression.

The Journal of cell biology - 1 May 1994

Kornbluth S, Dasso M, Newport J

Abstract excerpt

TC4, a ras-like G protein, has been implicated in the feedback pathway linking the onset of mitosis to the completion of DNA replication. In this report we find distinct roles for TC4 in both nuclear assembly and cell cycle progression. Mutant and wild-type forms of TC4 were added to Xenopus egg extracts capable of assembling nuclei around chromatin templates in vitro. We found that a mutant TC4 protein defective...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Replication

Share to Molecular Sequence Data

Share to Mutation

Share to Nuclear Proteins

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 8188741
DOI: 10.1083/jcb.125.4.705
PMCID: PMC2120068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression.PMID 8188741Read ↗

A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation.Semantic proximity Read ↗

[Cell cycle regulation and Ran/TC4 GTPase].Semantic proximity Read ↗

The interaction between Ran and NTF2 is required for cell cycle progression.Semantic proximity Read ↗

The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC1, RAN-GAP, and HTF9A/RANBP1.Semantic proximity Read ↗

The balance of RanBP1 and RCC1 is critical for nuclear assembly and nuclear transport.Semantic proximity Read ↗

Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.Semantic proximity Read ↗

Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis.Semantic proximity Read ↗

Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly.Semantic proximity Read ↗

Overexpression of D-type cyclins, E2F-1, SV40 large T antigen and HPV16 E7 rescue cell cycle arrest of tsBN462 cells caused by the CCG1/TAF(II)250 mutation.Semantic proximity Read ↗

RCC1, a regulator of mitosis, is essential for DNA replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.