Article
Analysis of cytochrome P450 2E1 genetic polymorphisms in relation to human lung cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 1994
Kato S, Shields P G, Caporaso N E, Sugimura H, Trivers G E, Tucker M A, Trump B F, Weston A, Harris C C
Abstract excerpt
Human cancer risk assessment using molecular genetic techniques is a rapidly emerging field. Many studies suggest that both inherited and acquired genetic predispositions play an important role in carcinogenesis. Cytochrome P450 (CYP) 2E1 is involved in the metabolic activation of N-nitrosamines and other low molecular weight compounds. A recently described genetic polymorphism of CYP2E1 [DraI restriction...
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