HIV type 1 infection of CD4+ T cells depends critically on basic amino acid residues in the V3 domain of envelope glycoprotein 120.

doi:10.1089/aid.1994.10.803

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Article

HIV type 1 infection of CD4+ T cells depends critically on basic amino acid residues in the V3 domain of envelope glycoprotein 120.

AIDS research and human retroviruses - 1 Jul 1994

Okada T, Patterson B K, Otto P A, Gurney M E

Abstract excerpt

The third variable domain (V3 domain) of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 is a major determinant of phenotypic variability. The V3 domain of HIV-1 has many basic amino acid residues. Lymphocytotropic HIV-1 tends to have a V3 domain with a higher density...

Topics

Amino Acid Sequence
Amino Acids
Base Sequence
CD4-Positive T-Lymphocytes
Cells, Cultured
DNA Probes
DNA, Viral
HIV Envelope Protein gp120
HIV-1
Humans
Molecular Sequence Data
Mutation

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