Article
Viral determinants of HIV-1 sufficient to extend tropism to macrophages are distinct from the determinants that control the cytopathic phenotype in HL-60 cells.
AIDS (London, England) - 15 Nov 1997
DiFronzo N L, Pise-Masison C A, Fernandez-Larsson R, Holland C A
Abstract excerpt
DESIGN: Infection of the human promyelocytic cell line HL-60 with NL4-3, a molecularly cloned HIV-1 strain that productively infects T cells, results in adaptation of the virus and production of a variant, NL4-3(M). Unlike NL4-3, NL4-3(M) has a rapid cytopathic effect in HL-60 and other myeloid c...
Topics
- Binding Sites
- Cytopathogenic Effect, Viral
- HIV Envelope Protein gp120
- HIV Envelope Protein gp41
- HIV-1
- HL-60 Cells
- Humans
- Macrophages
- Phenotype
- Reassortant Viruses