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Article

Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.

Science (New York, N.Y.) - 5 Jul 1991

Hwang S S, Boyle T J, Lyerly H K, Cullen B R

Abstract excerpt

Cells of the monocyte-macrophage lineage are targets for human immunodeficiency virus-1 (HIV-1) infection in vivo. However, many laboratory strains of HIV-1 that efficiently infect transformed T cell lines replicate poorly in macrophages. A 20-amino acid sequence from the macrophage-tropic BaL isolate of HIV-1 was sufficient to confer macrophage tropism on HTLV-IIIB, a T cell line--tropic isolate. This small...

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PMID: 1905842
DOI: 10.1126/science.1905842

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Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.PMID 1905842Read ↗

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