Article
Basic amino acid residues in the V3 loop of simian immunodeficiency virus envelope alter viral coreceptor tropism and infectivity but do not allow efficient utilization of CXCR4 as entry cofactor.
Virology - 5 Jun 2001
Meister S, Otto C, Papkalla A, Krumbiegel M, Pöhlmann S, Kirchhoff F
Abstract excerpt
In contrast to human immunodeficiency viruses type 1 and type 2 (HIV-1 and HIV-2, respectively), simian immunodeficiency virus (SIVmac) rarely uses CXCR4 (X4) for efficient entry into target cells. Basic amino acid residues in the V3 loop of HIV Env allow efficient coreceptor utilization of X4. Therefore, we investigated if similar changes in the SIVmac Env protein also mediate a coreceptor switch from CCR5 (R5)...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Cells, Cultured
- Humans
- Leukocytes, Mononuclear
- Molecular Sequence Data
- Mutation
- Protein Binding
- Receptors, CXCR4