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Article

Subtype-specific conservation of isoleucine 309 in the envelope V3 domain is linked to immune evasion in subtype C HIV-1 infection.

Virology - 15 Aug 2010

Lynch Rebecca M, Rong Rong, Li Bing, Shen Tongye, Honnen William, Mulenga Joseph, Allen Susan, Pinter Abraham, Gnanakaran S, Derdeyn Cynthia A

Abstract excerpt

The V3 region of the HIV-1 envelope (Env) glycoprotein gp120 is a key functional domain yet it exhibits distinct mutational patterns across subtypes. Here an invariant residue (Ile 309) was replaced with Leu in 7 subtype C patient-derived Envs from recent infection and 4 related neutralizing antibody escape variants that emerged later. For these 11 Envs, I309L did not alter replication in primary CD4 T cells;...

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Share to CD4 Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Envelope Protein gp120

Share to Immune Evasion

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Share to Receptors, CCR5

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Source

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Identifiers

PMID: 20494390
DOI: 10.1016/j.virol.2010.04.010
PMCID: PMC3987868

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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