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Article

Recombinant respiratory syncytial virus (RSV) bearing a set of mutations from cold-passaged RSV is attenuated in chimpanzees.

Journal of virology - 1 May 1998

Whitehead S S, Juhasz K, Firestone C Y, Collins P L, Murphy B R

Abstract excerpt

A set of five missense mutations previously identified by nucleotide sequence analysis of subgroup A cold-passaged (cp) respiratory syncytial virus (RSV) has been introduced into a recombinant wild-type strain of RSV. This recombinant virus, designated rA2cp, appears to replicate less efficiently in the upper and lower respiratory tracts of seronegative chimpanzees than either biologically derived or recombinant...

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Identifiers

PMID: 9557743
DOI: 10.1128/JVI.72.5.4467-4471.1998
PMCID: PMC109683

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