Recombinant respiratory syncytial virus (RSV) bearing a set of mutations from cold-passaged RSV is attenuated in chimpanzees.

doi:10.1128/JVI.72.5.4467-4471.1998

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Article

Recombinant respiratory syncytial virus (RSV) bearing a set of mutations from cold-passaged RSV is attenuated in chimpanzees.

Journal of virology - 1 May 1998

Whitehead S S, Juhasz K, Firestone C Y, Collins P L, Murphy B R

Abstract excerpt

A set of five missense mutations previously identified by nucleotide sequence analysis of subgroup A cold-passaged (cp) respiratory syncytial virus (RSV) has been introduced into a recombinant wild-type strain of RSV. This recombinant virus, designated rA2cp, appears to replicate less efficiently...

Topics

Animals
Base Sequence
Cell Line
DNA, Viral
Humans
Molecular Sequence Data
Mutation
Pan troglodytes
Recombination, Genetic
Respiratory Syncytial Virus, Human

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