Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant.

doi:10.1073/pnas.94.25.13961

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Article

Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 1997

Karron R A, Buonagurio D A, Georgiu A F, Whitehead S S, Adamus J E, Clements-Mann M L, Harris D O, Randolph V B, Udem S A, Murphy B R, Sidhu M S

Abstract excerpt

A live, cold-passaged (cp) candidate vaccine virus, designated respiratory syncytial virus (RSV) B1 cp-52/2B5 (cp-52), replicated efficiently in Vero cells, but was found to be overattenuated for RSV-seronegative infants and children. Sequence analysis of reverse-transcription-PCR-amplified fragm...

Topics

Animals
Child
Chlorocebus aethiops
Chromosome Mapping
Gene Deletion
Genes, Viral
HN Protein
Humans
Infant
Mutation
Respiratory Syncytial Virus Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Respiratory Syncytial Virus, Human

Vaccines, Attenuated

Vaccines, Synthetic

Vero Cells

Viral Envelope Proteins

Viral Proteins

Viral Vaccines

Source

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Identifiers

PMID: 9391135
DOI: 10.1073/pnas.94.25.13961
PMCID: PMC28415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9391135-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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