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Article

Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells.

The Journal of biological chemistry - 9 Dec 1994

Lo A C, Haass C, Wagner S L, Teplow D B, Sisodia S S

Abstract excerpt

The 4-kDa beta-amyloid peptide (A beta), a major constituent of parenchymal amyloid deposits in Alzheimer's disease, is derived from larger amyloid precursor proteins (APP). We have examined the metabolism of APP in Madin-Darby canine kidney cells stably transfected with cDNA encoding either wild-type human APP-695 or human APP-695 that harbors the Swedish double mutation associated with familial early-onset...

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Source

Identifiers

PMID: 7983032

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells.PMID 7983032Read ↗

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.Semantic proximity Read ↗

Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease.Semantic proximity Read ↗

Cellular mechanisms of beta-amyloid production and secretion.Semantic proximity Read ↗

Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein.Semantic proximity Read ↗

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.Semantic proximity Read ↗

Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that interfere with protein metabolism.Semantic proximity Read ↗

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.Semantic proximity Read ↗

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