Article
Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells.
The Journal of biological chemistry - 9 Dec 1994
Lo A C, Haass C, Wagner S L, Teplow D B, Sisodia S S
Abstract excerpt
The 4-kDa beta-amyloid peptide (A beta), a major constituent of parenchymal amyloid deposits in Alzheimer's disease, is derived from larger amyloid precursor proteins (APP). We have examined the metabolism of APP in Madin-Darby canine kidney cells stably transfected with cDNA encoding either wild...
Topics
- Amino Acid Sequence
- Amyloid Precursor Protein Secretases
- Amyloid beta-Protein Precursor
- Animals
- Aspartic Acid
- Aspartic Acid Endopeptidases
- Base Sequence
- Cells, Cultured
- Dogs
- Endopeptidases
- Hydrolysis
- Kidney
- Kinetics
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Subcellular Fractions