Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.

doi:10.1074/jbc.271.16.9390

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Article

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.

The Journal of biological chemistry - 19 Apr 1996

Thinakaran G, Teplow D B, Siman R, Greenberg B, Sisodia S S

Abstract excerpt

The 4-kDa beta-amyloid peptide (Abeta), a principal component of parenchymal amyloid deposits in Alzheimer's disease, is derived from amyloid precursor proteins (APP). To identify potential intracellular compartments involved in Abeta production, we expressed human APP-695 (APPwt) and APP-695 har...

Topics

Alzheimer Disease
Amino Acid Sequence
Amyloid Precursor Protein Secretases
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Animals
Aspartic Acid Endopeptidases
Cell Line
Cell Membrane
Endopeptidases
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Golgi Apparatus

Humans

Kinetics

Mice

Models, Neurological

Molecular Sequence Data

Mutation

Source

Open in PubMed

Identifiers

PMID: 8621605
DOI: 10.1074/jbc.271.16.9390

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8621605-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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