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Article

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.

The Journal of biological chemistry - 19 Apr 1996

Thinakaran G, Teplow D B, Siman R, Greenberg B, Sisodia S S

Abstract excerpt

The 4-kDa beta-amyloid peptide (Abeta), a principal component of parenchymal amyloid deposits in Alzheimer's disease, is derived from amyloid precursor proteins (APP). To identify potential intracellular compartments involved in Abeta production, we expressed human APP-695 (APPwt) and APP-695 harboring the Swedish double mutation (APPswe) associated with familial early-onset Alzheimer's disease, in mouse N2a...

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Source

Identifiers

PMID: 8621605
DOI: 10.1074/jbc.271.16.9390

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.PMID 8621605Read ↗

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The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.Semantic proximity Read ↗

Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that interfere with protein metabolism.Semantic proximity Read ↗

Trafficking and proteolytic processing of APP.Semantic proximity Read ↗

Cellular mechanisms of beta-amyloid production and secretion.Semantic proximity Read ↗

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.Semantic proximity Read ↗

Enhanced Release of Amyloid -Protein from Codon 670/671 Swedish Mutant -Amyloid Precursor Protein Occurs in Both Secretory and Endocytic PathwaysSemantic proximity Read ↗

Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations.Semantic proximity Read ↗

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Advances in the cell biology of the trafficking and processing of amyloid precursor protein: impact of familial Alzheimer's disease mutations.Semantic proximity Read ↗

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