Article
The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.
Nature medicine - 1 Dec 1995
Haass C, Lemere C A, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe D J
Abstract excerpt
Several missense mutations causing early-onset Alzheimer's disease (AD) have been described in the gene coding for the beta-amyloid precursor protein (beta APP). A double mutation found in a Swedish family is located before the amyloid beta-peptide (A beta) region of beta APP and results in the i...
Topics
- Age of Onset
- Aged
- Alzheimer Disease
- Amino Acid Sequence
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Aspartic Acid Endopeptidases
- Brain
- Endopeptidases
- Golgi Apparatus
- Humans
- Molecular Sequence Data
- Mutation
- Sweden