Article
The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.
Nature medicine - 1 Dec 1995
Haass C, Lemere C A, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe D J
Abstract excerpt
Several missense mutations causing early-onset Alzheimer's disease (AD) have been described in the gene coding for the beta-amyloid precursor protein (beta APP). A double mutation found in a Swedish family is located before the amyloid beta-peptide (A beta) region of beta APP and results in the increased production and secretion of A beta. Here we show that the increased production of A beta results from a...
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