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Article

Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Del Prete Dolores, Suski Jan M, Oulès Bénédicte, Debayle Delphine, Gay Anne Sophie, Lacas-Gervais Sandra, Bussiere Renaud, Bauer Charlotte, Pinton Paolo, Paterlini-Bréchot Patrizia, Wieckowski Mariusz R, Checler Frédéric, Chami Mounia

Abstract excerpt

Alteration of mitochondria-associated membranes (MAMs) has been proposed to contribute to the pathogenesis of Alzheimer's disease (AD). We studied herein the subcellular distribution, the processing, and the protein interactome of the amyloid-β protein precursor (AβPP) and its proteolytic products in MAMs. We reveal that AβPP and its catabolites are present in MAMs in cellular models overexpressing wild type AβPP...

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PMID: 27911326
DOI: 10.3233/JAD-160953
PMCID: PMC5181669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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