Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein.

doi:10.1074/jbc.270.45.26727

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Article

Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein.

The Journal of biological chemistry - 10 Nov 1995

Martin B L, Schrader-Fischer G, Busciglio J, Duke M, Paganetti P, Yankner B A

Abstract excerpt

beta-Amyloid (beta A) is a normal metabolic product of the amyloid precursor protein (APP) that accumulates in senile plaques in Alzheimer's disease. Cells that express the Swedish mutant APP (Sw-APP) associated with early onset Alzheimer's disease overproduce beta A. In this report, we show that...

Topics

Alzheimer Disease
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Animals
Cell Line
Humans
Intracellular Fluid
Kinetics
Mutation
Protein Processing, Post-Translational
Temperature

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