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Article

Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein.

The Journal of biological chemistry - 10 Nov 1995

Martin B L, Schrader-Fischer G, Busciglio J, Duke M, Paganetti P, Yankner B A

Abstract excerpt

beta-Amyloid (beta A) is a normal metabolic product of the amyloid precursor protein (APP) that accumulates in senile plaques in Alzheimer's disease. Cells that express the Swedish mutant APP (Sw-APP) associated with early onset Alzheimer's disease overproduce beta A. In this report, we show that expression of Sw-APP gives rise to cell-associated beta A, which is not detected in cells that express wild-type APP....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7592902
DOI: 10.1074/jbc.270.45.26727

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein.PMID 7592902Read ↗

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The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.Semantic proximity Read ↗

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Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells.Semantic proximity Read ↗

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Enhanced Release of Amyloid -Protein from Codon 670/671 Swedish Mutant -Amyloid Precursor Protein Occurs in Both Secretory and Endocytic PathwaysSemantic proximity Read ↗

Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway.Semantic proximity Read ↗

Differential effects of the swedish mutant amyloid precursor protein on beta-amyloid accumulation and secretion in neurons and nonneuronal cells.Semantic proximity Read ↗

The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.Semantic proximity Read ↗

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