Article
Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.
Proceedings of the National Academy of Sciences of the United States of America - 6 Dec 1994
Citron M, Vigo-Pelfrey C, Teplow D B, Miller C, Schenk D, Johnston J, Winblad B, Venizelos N, Lannfelt L, Selkoe D J
Abstract excerpt
The 39- to 43-amino acid amyloid beta-protein (A beta), which is progressively deposited in cerebral plaques and blood vessels in Alzheimer disease (AD), is secreted by cultured human cells during normal metabolism. In studies of cell lines transfected with beta-amyloid precursor protein (beta APP) cDNAs, the beta APP mutation K670N/M671L found in a Swedish familial AD (FAD) pedigree has previously been shown to...
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