Article
A-Raf: A new star of the family of raf kinases.
Critical reviews in biochemistry and molecular biology - 1 Jan 2015
An Su, Yang Yang, Ward Richard, Liu Ying, Guo Xiao-Xi, Xu Tian-Rui
Abstract excerpt
The Ras-Raf-MEK-MAPK (mitogen-activated protein kinase)-signaling pathway plays a key role in the regulation of many cellular functions, including cell proliferation, differentiation and transformation, by transmitting signals from membrane receptors to various cytoplasmic and nuclear targets. One of the key components of this pathway is the serine/threonine protein kinase, Raf. The Raf family kinases (A-Raf,...
Topics
- Animals
- Drug Resistance, Neoplasm
- Endocytosis
- Gene Expression Regulation, Neoplastic
- Humans
- Mutation
- Neoplasms
- Protein Interaction Maps
- Protein Isoforms
- Protein Kinase Inhibitors
- Proto-Oncogene Proteins A-raf