Article
Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding.
Molecular biology of the cell - 1 Oct 2005
Zhu Jun, Balan Vitaly, Bronisz Agnieszka, Balan Karina, Sun Hengrui, Leicht Deborah T, Luo Zhijun, Qin Jun, Avruch Joseph, Tzivion Guri
Abstract excerpt
The Ras-Raf-MAPK cascade is a key growth-signaling pathway and its uncontrolled activation results in cell transformation. Although the general features of the signal transmission along the cascade are reasonably defined, the mechanisms underlying Raf activation remain incompletely understood. Here, we show that Raf-1 dephosphorylation, primarily at epidermal growth factor (EGF)-induced sites, abolishes Raf-1...
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