Article
Activation of an imprinted allele of the insulin-like growth factor II gene implicated in rhabdomyosarcoma.
The Journal of clinical investigation - 1 Jul 1994
Zhan S, Shapiro D N, Helman L J
Abstract excerpt
The insulin-like growth factor II (IGF2) gene is exclusively silent at the maternal allele in the mouse as well as in normal human tissues and is expressed at a high level in rhabdomyosarcoma (RMS). We report here that the normally imprinted allele of the IGF2 gene is activated in RMS tumors as well as in one RMS cell line. Since overexpression of IGF2 has been shown to be important in the pathogenesis of RMS,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.