Activation of an imprinted allele of the insulin-like growth factor II gene implicated in rhabdomyosarcoma.

doi:10.1172/JCI117344

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Article

Activation of an imprinted allele of the insulin-like growth factor II gene implicated in rhabdomyosarcoma.

The Journal of clinical investigation - 1 Jul 1994

Zhan S, Shapiro D N, Helman L J

Abstract excerpt

The insulin-like growth factor II (IGF2) gene is exclusively silent at the maternal allele in the mouse as well as in normal human tissues and is expressed at a high level in rhabdomyosarcoma (RMS). We report here that the normally imprinted allele of the IGF2 gene is activated in RMS tumors as w...

Topics

Alleles
Base Sequence
Chromosome Deletion
Fetus
Gene Expression Regulation, Neoplastic
Humans
Insulin-Like Growth Factor II
Molecular Sequence Data
Rhabdomyosarcoma
Tumor Cells, Cultured

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