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Article

Prognostic significance of p53 mutation and p53 overexpression in advanced epithelial ovarian cancer: a Gynecologic Oncology Group Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 Oct 2003

Havrilesky Laura, Darcy kathleen M, Hamdan Hasnah, Priore Roger L, Leon Jorge, Bell Jeffrey, Berchuck Andrew

Abstract excerpt

PURPOSE: The prognostic significance of p53 mutations and overexpression in advanced epithelial ovarian cancers was examined in primary tumors from 125 patients participating in a Gynecologic Oncology Group randomized phase III treatment protocol. PATIENTS AND METHODS: Mutational analysis of p53 was performed in RNA or genomic DNA extracted from frozen tumor. An immunohistochemistry assay was used to detect p53...

Topics

DNA Mutational Analysis
Disease-Free Survival
Female
Genes, p53
Humans
Immunohistochemistry
Middle Aged
Mutation
Neoplasms, Glandular and Epithelial
Ovarian Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prognosis

Survival Analysis

Treatment Outcome

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 14551300
DOI: 10.1200/JCO.2003.11.052

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