Article
p53 mutations and expression in ovarian cancers: correlation with overall survival.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 Jan 1999
Wen W H, Reles A, Runnebaum I B, Sullivan-Halley J, Bernstein L, Jones L A, Felix J C, Kreienberg R, el-Naggar A, Press M F
Abstract excerpt
The p53 gene is altered in approximately 50% of all human malignancies. p53 overexpression, identified by immunohistochemistry, and p53 mutations, identified by single-strand conformational polymorphism (SSCP) and DNA sequencing, have been described in ovarian cancers. p53 overexpression has been...
Topics
- Adult
- Aged
- Base Sequence
- Female
- Genes, p53
- Humans
- Immunohistochemistry
- Middle Aged
- Mutation
- Open Reading Frames
- Ovarian Neoplasms
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Tumor Suppressor Protein p53