Article
p53 mutations and expression in ovarian cancers: correlation with overall survival.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 Jan 1999
Wen W H, Reles A, Runnebaum I B, Sullivan-Halley J, Bernstein L, Jones L A, Felix J C, Kreienberg R, el-Naggar A, Press M F
Abstract excerpt
The p53 gene is altered in approximately 50% of all human malignancies. p53 overexpression, identified by immunohistochemistry, and p53 mutations, identified by single-strand conformational polymorphism (SSCP) and DNA sequencing, have been described in ovarian cancers. p53 overexpression has been correlated with poor outcome for women with ovarian cancer in some studies. With only limited data, the assumption has...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.