Article
P53 mutation does not affect prognosis in ovarian epithelial malignancies.
The Journal of pathology - 1 May 2001
Fallows S, Price J, Atkinson R J, Johnston P G, Hickey I, Russell S E
Abstract excerpt
Mutations of the p53 tumour suppressor gene have been found in most human cancers, including ovarian epithelial malignancies. This study investigated whether the presence or absence of p53 mutation was associated with outcome following platinum-based chemotherapy in patients with ovarian cancer. DNA samples from tumour tissue and blood were obtained from 73 patients with primary tumours, 50 of whom received...
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