Pharmacokinetics, metabolism and renal excretion of sulfatroxazole and its 5-hydroxy- and N4-acetyl-metabolites in man.

doi:10.1002/bdd.2510070305

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Article

Pharmacokinetics, metabolism and renal excretion of sulfatroxazole and its 5-hydroxy- and N4-acetyl-metabolites in man.

Biopharmaceutics & drug disposition - 1 Jan 2000

Vree T B, Hekster Y A, Tijhuis M W, Termond E F, Nouws J F

Abstract excerpt

Hydroxylation is the predominant pathway of metabolism for sulfatroxazole in the body, accounting for 70 per cent of the dose. Fifteen per cent of the dose is acetylated unimodally and 10 per cent is excreted unchanged. The half-lives of sulfatroxazole and its metabolites 5-hydroxysulfatroxazole...

Topics

Acetylation
Adult
Female
Half-Life
Humans
Hydroxylation
Kinetics
Male
Phenotype
Probenecid
Protein Binding
Sulfamethoxazole

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