Article
Plasma concentrations and pharmacokinetics of dihydralazine after single oral doses to human subjects.
Biopharmaceutics & drug disposition - 1 Jan 2000
Waller A R, Chasseaud L F, Taylor T, Darragh A, O'Kelly D A
Abstract excerpt
After single oral doses of 20 mg of a suspension of dihydralazine sulphate to human subjects, the peak of mean plasma concentrations of dihydralazine of 47.0 ng ml-1 +/- 11.0 standard deviation (S.D.) (n = 7) was reached at 1 h. Mean concentrations declined biphasically with apparent half-lives of 0.57 and 4.96 h respectively. Dihydralazine was partly converted to hydralazine. The peak of mean plasma...
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