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Article

Involvement of glutathione in cis-platinum toxicity in Escherichia coli K12.

Toxicology - 1 Jan 1992

Salles B, Calsou P

Abstract excerpt

Among the various biochemical functions assumed by the tripeptide glutathione (GSH), a role in cell protection against xenobiotics has been well established. In the case of resistance to cis-diamminedichloroplatinum(II) (CDDP) this role is controversial. CDDP reacts with nucleophiles and binds covalently to DNA, its ultimate target. We addressed the question of a putative role of GSH as a secondary non-essential...

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Source

Identifiers

PMID: 1585387
DOI: 10.1016/0300-483x(92)90184-g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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