Involvement of glutathione in cis-platinum toxicity in Escherichia coli K12.

doi:10.1016/0300-483x(92)90184-g

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Article

Involvement of glutathione in cis-platinum toxicity in Escherichia coli K12.

Toxicology - 1 Jan 1992

Salles B, Calsou P

Abstract excerpt

Among the various biochemical functions assumed by the tripeptide glutathione (GSH), a role in cell protection against xenobiotics has been well established. In the case of resistance to cis-diamminedichloroplatinum(II) (CDDP) this role is controversial. CDDP reacts with nucleophiles and binds co...

Topics

Chromatography, High Pressure Liquid
Cisplatin
DNA Repair
DNA, Bacterial
Drug Resistance, Microbial
Escherichia coli
Glutathione
Mutation

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