Article
MNNG-induced [corrected] RecBCD dependent DNA degradation in recA13 mutant cells is not the basis of their hypersensitivity to this agent.
Mutation research - 1 Jul 1998
Chovanec M, Vlasáková D, Margison G P, Näslund M, Brozmanová J
Abstract excerpt
We have examined the hypersensitivity of Escherichia coli recA13 mutant cells to killing by N-methyl-N'-nitro-N-nitro-soguanidine (MNNG) and have shown out that despite MNNG-induced adaptation they remained vastly more sensitive to the cytotoxic effect of this agent than wild type cells. Because...
Topics
- Adaptation, Biological
- Alkyl and Aryl Transferases
- DNA Repair
- DNA, Bacterial
- Escherichia coli
- Exodeoxyribonuclease V
- Exodeoxyribonucleases
- Methylnitronitrosoguanidine
- Mutagens
- Mutation
- Rec A Recombinases