Article
Preferential amplification of the paternal allele in neuroblastomas with N-myc amplification.
Progress in clinical and biological research - 1 Jan 1994
Cheng J M, Hiemstra J L, Schneider S S, Kaufman B A, Naumova A, Cheung N K, Cohn S L, Diller L, Sapienza C, Brodeur G M
Abstract excerpt
There is increasing evidence that imprinting plays an important role in influencing the parental origin of genes involved in cancer-specific rearrangements. In advanced stage neuroblastomas, both allelic loss of the short arm of chromosome 1 (1p) and amplification of the proto-oncogene N-myc are often seen. Therefore, we analyzed 22 human neuroblastomas with N-myc amplification to determine the parental origin of...
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