Article
Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas.
Nature genetics - 1 Jun 1993
Cheng J M, Hiemstra J L, Schneider S S, Naumova A, Cheung N K, Cohn S L, Diller L, Sapienza C, Brodeur G M
Abstract excerpt
Genomic imprinting plays a role in influencing the parental origin of genes involved in cancer-specific rearrangements. We have analysed 22 neuroblastomas with N-myc amplification to determine the parental origin of the amplified N-myc allele and the allele that is deleted from chromosome 1p. We...
Topics
- Adrenal Gland Neoplasms
- Adult
- Alleles
- Animals
- Child, Preschool
- DNA, Neoplasm
- Female
- Gene Amplification
- Gene Deletion
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Genes, myc
- Humans
- Male
- Mice
- Models, Genetic
- Neuroblastoma
- Polymorphism, Restriction Fragment Length