Article
No evidence for the presence of an imprinted neuroblastoma suppressor gene within chromosome sub-band 1p36.3.
Cancer research - 15 Nov 2002
Hogarty Michael D, Winter Cynthia L, Liu Xueyuan, Guo Chun, White Peter S, Look A Thomas, Brodeur Garrett M, Maris John M
Abstract excerpt
Deletion of the distal short arm of chromosome 1 occurs in 35% of primary neuroblastomas (NBs). These deletions tend to be large and extend to the telomere, but a common region within sub-band 1p36.3 is consistently lost. Despite intensive investigation, no candidate tumor suppressor gene within this region has been shown to undergo tumor-specific mutation consistent with biallelic inactivation. In addition,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.