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Article

Loss of allelic heterozygosity on distal chromosome 1p in Merkel cell carcinoma. A marker of neural crest origins?

Cancer genetics and cytogenetics - 1 Jul 1991

Harnett P R, Kearsley J H, Hayward N K, Dracopoli N C, Kefford R F

Abstract excerpt

The location of genes involved in tumor evolution has been inferred from experiments in which loss of constitutional heterozygosity has been detected in tumor DNA at high frequency in specific chromosome regions. For example, cytogenetic and molecular abnormalities on chromosome 1p have been reported in tumors such as malignant melanoma and neuroblastoma which arise in cells derived from embryonic neural crest...

Topics

Alleles
Carcinoma, Merkel Cell
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 1
Genes, Tumor Suppressor
Genetic Markers
Heterozygote
Humans
Neoplasm Metastasis
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Skin Neoplasms

Source

Identifiers

PMID: 1676609
DOI: 10.1016/0165-4608(91)90037-u

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1676609-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Loss of allelic heterozygosity on distal chromosome 1p in Merkel cell carcinoma. A marker of neural crest origins?PMID 1676609Read ↗

Loss of heterozygosity for alleles on chromosomes 11q and 14q in neuroblastoma.Semantic proximity Read ↗

Allelic status of chromosome 1 in neoplasms of the nervous system.Semantic proximity Read ↗

Deletion mapping of the short arm of chromosome 1 identifies a common region of deletion distal to D1S496 in human meningiomas.Semantic proximity Read ↗

Chromosomal allele loss in primary cutaneous melanoma is heterogeneous and correlates with proliferation.Semantic proximity Read ↗

Loss of heterozygosity identifies multiple sites of allelic deletions on chromosome 1 in human male germ cell tumors.Semantic proximity Read ↗

Clinical categories of neuroblastoma are associated with different patterns of loss of heterozygosity on chromosome arm 1p.Semantic proximity Read ↗

Identification of two distinct deleted regions on the short arm of chromosome 1 and rare mutation of the CDKN2C gene from 1p32 in oligodendroglial tumors.Semantic proximity Read ↗

Allelic loss at 1p is associated with tumor progression of meningiomas.Semantic proximity Read ↗

Loss of heterozygosity at 1p36 predicts poor prognosis in gastrointestinal stromal/smooth muscle tumors.Semantic proximity Read ↗

There may be two tumor suppressor genes on chromosome arm 1p closely associated with biologically distinct subtypes of neuroblastoma.Semantic proximity Read ↗

Allelic loss of chromosome 1p36 in neuroblastoma is of preferential maternal origin and correlates with N-myc amplification.Semantic proximity Read ↗

No evidence for the presence of an imprinted neuroblastoma suppressor gene within chromosome sub-band 1p36.3.Semantic proximity Read ↗

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