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Article

Loss of one HuD allele on chromosome #1p selects for amplification of the N-myc proto-oncogene in human neuroblastoma cells.

Oncogene - 2 Feb 2006

Grandinetti K B, Spengler B A, Biedler J L, Ross R A

Abstract excerpt

In human neuroblastoma tumors, amplification of the N-myc proto-oncogene and loss of all or part of the short arm of chromosome #1 are both associated with a poor prognosis. Accruing evidence indicates that it is the absence of one allele of the HuD (ELAVL4) gene, encoding the neuronal-specific RNA-binding protein HuD and localized to 1p34, that is linked to amplification. In 12 human neuroblastoma cell lines,...

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Share to Chromosome Deletion
Share to Chromosomes, Human, Pair 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ELAV Proteins

Share to Gene Amplification

Share to In Situ Hybridization, Fluorescence

Share to Proto-Oncogene Mas

Share to Proto-Oncogene Proteins c-myc

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Source

Identifiers

PMID: 16278682
DOI: 10.1038/sj.onc.1209095

Genes

ELAVL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of one HuD allele on chromosome #1p selects for amplification of the N-myc proto-oncogene in human neuroblastoma cells.PMID 16278682Read ↗

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