Article
Malignant phenotype correlating with drug resistance in two human neuroblastoma cell lines.
Journal of neuro-oncology - 1 Jan 1994
Wollman Y, Shahar I, Goldstein M, Leibovici J
Abstract excerpt
The main cause for the failure of chemotherapeutic treatment of advanced cancer probably lies in the emergence of drug resistance clones. In the present study we compared the sensitivity to adriamycin (ADR) and the capacity of ADR uptake in two human neuroblastoma cell lines differing in properties relevant to metastatic potential, the GP2 and MB, of low- and high-malignancy phenotype, respectively. Examination...
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