Article
Sensitivity to thermochemotherapy of AKR lymphoma and B16 melanoma variants of malignancy.
Clinical & experimental metastasis - 1 Jan 2000
Leibovici J, Klorin G, Huszar M, Hoenig S, Klein O, Michowitz M, Pinchassov A
Abstract excerpt
Drug resistance, which so often accompanies tumor progression, has been shown to be related to changes in membrane properties which may result in decreased drug accumulation in the tumor cell. A correlation between sensitivity to thermochemotherapy and degree of malignancy was found in the AKR lymphoma system. Hyperthermia increased adriamycin (ADR) uptake and concomitantly its cytotoxicity to AKR lymphoma cells....
Topics
- Animals
- Biological Transport
- Cell Line
- Combined Modality Therapy
- Doxorubicin
- Genetic Variation
- Hyperthermia, Induced
- Lymphoma
- Male
- Melanoma, Experimental
- Mice