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Article

Influence of multidrug resistance on (18)F-FCH cellular uptake in a glioblastoma model.

European journal of nuclear medicine and molecular imaging - 1 Aug 2009

Vanpouille Claire, Le Jeune Nathalie, Kryza David, Clotagatide Anthony, Janier Marc, Dubois Francis, Perek Nathalie

Abstract excerpt

PURPOSE: Multidrug resistance, aggressiveness and accelerated choline metabolism are hallmarks of malignancy and have motivated the development of new PET tracers like (18)F-FCH, an analogue of choline. Our aim was to study the relationship of multidrug resistance of cultured glioma cell lines and (18)F-FCH tracer uptake. METHODS: We used an in vitro multidrug-resistant (MDR) glioma model composed of sensitive...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19300998
DOI: 10.1007/s00259-009-1101-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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