Evidence for a functional interaction between the beta chain of major histocompatibility complex class II and the T cell receptor alpha chain during recognition of a bacterial superantigen.

Abstract excerpt

Several studies have suggested that there is a direct interaction between the T cell receptor (TCR) and the major histocompatibility complex (MHC) molecule during T cell recognition of superantigen. To further investigate this possibility, we have analyzed T cell recognition of a bacterial superantigen, Staphylococcal enterotoxin B (SEB), presented by a series of mutant murine I-Ek molecules in which residues of...

Topics

• Animals
• Antigen Presentation
• CHO Cells
• Cricetinae
• Enterotoxins
• Histocompatibility Antigens Class II
• Hybridomas
• Mutation
• Receptors, Antigen, T-Cell, alpha-beta
• Staphylococcus aureus