Antibodies are capable of directing superantigen-mediated T cell killing of chronic B lymphocytic leukemia cells.

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Article

Antibodies are capable of directing superantigen-mediated T cell killing of chronic B lymphocytic leukemia cells.

Leukemia - 1 Sept 1995

Gidlöf C, Dohlsten M, Kalland T, Tötterman T H

Abstract excerpt

The bacterial superantigen staphylococcal enterotoxin A (SEA) is a highly potent activator of cytotoxic T cells when presented on MHC class II molecules of target cells. Our earlier studies showed that such SEA-directed T cells efficiently killed chronic B lymphocytic leukemia (B-CLL) cells. With the ultimate goal to replace the natural specificity of SEA for MHC class II molecules with the specificity of a...

Topics

Antibodies, Monoclonal
Antigens, CD
Antigens, CD19
Antigens, Differentiation, B-Lymphocyte
Enterotoxins
Epitopes
HLA-DR Antigens
Humans
Immunotherapy
Intercellular Adhesion Molecule-1
Leukemia, B-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Recombinant Fusion Proteins

Superantigens

T-Lymphocytes, Cytotoxic

Time Factors

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 7544852

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7544852-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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