Article
Antibodies are capable of directing superantigen-mediated T cell killing of chronic B lymphocytic leukemia cells.
Leukemia - 1 Sept 1995
Gidlöf C, Dohlsten M, Kalland T, Tötterman T H
Abstract excerpt
The bacterial superantigen staphylococcal enterotoxin A (SEA) is a highly potent activator of cytotoxic T cells when presented on MHC class II molecules of target cells. Our earlier studies showed that such SEA-directed T cells efficiently killed chronic B lymphocytic leukemia (B-CLL) cells. With the ultimate goal to replace the natural specificity of SEA for MHC class II molecules with the specificity of a...
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