Article
Superantigen vaccines: a comparative study of genetically attenuated receptor-binding mutants of staphylococcal enterotoxin A.
The Journal of infectious diseases - 1 Aug 1996
Bavari S, Dyas B, Ulrich R G
Abstract excerpt
Superantigens exert their pathologic effects by direct binding to major histocompatibility complex (MHC) class II molecules and T cell antigen receptors (TCR), thus circumventing the normal, antigen-specific immune response. A direct link between disease and toxin suggests an excellent opportunit...
Topics
- Animals
- Enterotoxins
- Genes, MHC Class II
- Histocompatibility Antigens Class II
- Male
- Mice
- Mice, Inbred C57BL
- Mutation
- Receptors, Antigen, T-Cell
- Staphylococcal Infections
- Staphylococcal Vaccines
- Superantigens
