Article
Monoclonal antibodies defining functional sites on the toxin superantigen staphylococcal enterotoxin B.
The Journal of experimental medicine - 1 Aug 1994
Hamad A R, Herman A, Marrack P, Kappler J W
Abstract excerpt
Four monoclonal antibodies (mAbs) were produced binding to four nonoverlapping epitopes on the superantigen staphylococcal enterotoxin B (SEB). The mAbs were tested for their ability to detect SEB bound to major histocompatibility complex (MHC) class II, to inhibit SEB binding to MHC class II, to inhibit SEB stimulation of T cell hybridomas, to bind to various nonfunctional mutants of SEB, and to capture and...
Topics
- Animals
- Antibodies, Monoclonal
- Antibody Specificity
- Enterotoxins
- Epitopes
- Histocompatibility Antigens Class II
- Hybridomas
- Mice
- Mutation
- Protein Conformation
- Staphylococcus aureus