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Article

Conserved T-cell receptor class II major histocompatibility complex contact detected in a T-lymphocyte population.

Immunology - 1 Oct 1998

Feng M, Chou D, Liaw Y, Lai M

Abstract excerpt

T-cell receptor (TCR) interacts with an antigenic peptide deeply buried in the major histocompatibility complex (MHC) molecule. How class II MHC is contacted by TCR during antigen recognition remains largely elusive. Here we used a panel of I-Ek mutants to identify two I-Ek residues that were frequently contacted by TCR among a large pool of T cells specific for the same antigen. The restricted TCR interaction...

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Identifiers

PMID: 9824474
DOI: 10.1046/j.1365-2567.1998.00589.x
PMCID: PMC1364303

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