Article
Conserved T-cell receptor class II major histocompatibility complex contact detected in a T-lymphocyte population.
Immunology - 1 Oct 1998
Feng M, Chou D, Liaw Y, Lai M
Abstract excerpt
T-cell receptor (TCR) interacts with an antigenic peptide deeply buried in the major histocompatibility complex (MHC) molecule. How class II MHC is contacted by TCR during antigen recognition remains largely elusive. Here we used a panel of I-Ek mutants to identify two I-Ek residues that were fre...
Topics
- Animals
- Antigen Presentation
- Dose-Response Relationship, Drug
- Epitopes
- Histocompatibility Antigens Class II
- Hybridomas
- Mice
- Mice, Inbred A
- Mice, Inbred C3H
- Mice, Inbred Strains
- Mutation
- Peptide Mapping
- Protein Structure, Secondary
- Receptors, Antigen, T-Cell